Browsing by Author "Sener, Goksel"
Now showing items 1-13 of 13
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Ameliorative effects of riboflavin on acetic acid-induced colonic injury in rats
Karakoyun, Berna; Ertas, Busra; Yuksel, Meral; Akakin, Dilek; Cevik, Ozge; Sener, Goksel (WILEY, 2018)Riboflavin (RF) has been found to be a promising antioxidant and/or anti-inflammatory agent in several studies. However, the effect of RF against acetic acid (AA)-induced colonic injury is currently unknown. This study ... -
Beneficial effects of quercetin on rat urinary bladder after spinal cord injury
Cevik, Ozge; Ersahim, Mehmet; Sener, T. Emre; Tinay, Ilker; Tarcan, Tufan; Cetinel, Sule; Sener, Azize; Toklu, Hale Z.; Sener, Goksel (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2013)Background: Spinal cord injury (SCI) leads to an inflammatory response and generates oxidative stress, which has deleterious effects on the function of several organ systems, including the urinary bladder. The present study ... -
The Effects of Melatonin on Ethylene Glycol-induced Nephrolithiasis: Role on Osteopontin mRNA Gene Expression
Sener, Tarik Emre; Sener, Goksel; Cevik, Ozge; Eker, Pinar; Cetinel, Sule; Traxer, Olivier; Tanidir, Yiloren; Akbal, Cem (ELSEVIER SCIENCE INC, 2017)OBJECTIVE To evaluate the protective effects of melatonin (Mel) on an ethylene glycol (EG)-induced nephrolithiasis model in rats. MATERIALS AND METHODS Thirty-two Wistar albino rats were divided into 4 groups: control, EG, ... -
Effects of Myrtus communis extract treatment in bile duct ligated rats
Sen, Ali; Ozkan, Sevil; Recebova, Kafiye; Cevik, Ozge; Ercan, Feriha; Demirci, Elif Kervancioglu; Bitis, Leyla; Sener, Goksel (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2016)Background: The aim of our study was to investigate the antifibrotic and antioxidant effects of Myrtus communis subsp. communis (MC) extract against liver injury and fibrosis occurring in rats with biliary obstruction. ... -
Estrogen receptor agonists alleviate cardiac and renal oxidative injury in rats with renovascular hypertension
Kumral, Zarife Nigar Ozdemir; Kolgazi, Meltem; Ustunova, Savas; Cakir, Ozguer Kasimay; Cevik, Ozge Dagdeviren; Sener, Goksel; Yegen, Berrak C. (TAYLOR & FRANCIS INC, 2016)Although endogenous estrogen is known to offer cardiac and vascular protection, the involvement of estrogen receptors in mediating the protective effect of estrogen on hypertension-induced cardiovascular and renal injury ... -
Investigation into the role of the cholinergic system in radiation-induced damage in the rat liver and ileum
Ozyurt, Hazan; Ozden, A. Sevgi; Cevik, Ozge; Ozgen, Zerrin; Cadirci, Selin; Elmas, Merve Acikel; Ercan, Feriha; Sener, Goksel; Goren, M. Z. (OXFORD UNIV PRESS, 2014)It has been previously shown that acetylcholine (ACh) may affect pro-inflammatory and anti-inflammatory cytokines. The role of the cholinergic system in radiation-induced inflammatory responses and tissue damage remains ... -
Melatonin and tadalafil treatment improves erectile dysfunction after spinal cord injury in rats
Tavukcu, Hasan Huseyin; Sener, Tarik Emre; Tinay, Ilker; Akbal, Cem; Ersahin, Mehmet; Cevik, Ozge; Cadirci, Selin; Reiter, Russel J.; Sener, Goksel (WILEY, 2014)Oxidative stress plays an important role both in spinal cord injury (SCI) and erectile dysfunction (ED). The present study investigated the effects of melatonin and tadalafil treatment alone or in combination on SCI-induced ... -
Montelukast inhibits caspase-3 activity and ameliorates oxidative damage in the spinal cord and urinary bladder of rats with spinal cord injury
Ersahin, Mehmet; Cevik, Ozge; Akakin, Dilek; Sener, Azize; Ozbay, Latif; Yegen, Berrak C.; Sener, Goksel (ELSEVIER SCIENCE INC, 2012)Spinal cord injury (SCI) leads to an inflammatory response that generates substantial secondary damage within the tissue besides the primary damage. Leukotrienes are biologically active 5-lipoxygenase products of arachidonic ... -
The preventive and curative effects of melatonin against abdominal aortic aneurysm in rats
Tekin, Gozde; Isbir, Selim; Sener, Goksel; Cevik, Ozge; Cetinel, Sule; Dericioglu, Okan; Arsan, Sinan; Cobanoglu, Adnan (MOSBY-ELSEVIER, 2018)Objective: Oxygen free radicals are important components involved in the histopathologic tissue alterations observed during abdominal aortic aneurysms (AAAs). This study examined whether melatonin has protective or therapeutic ... -
Protective effect of platelet-rich plasma on urethral injury model of male rats
Tavukcu, Hasan H.; Aytac, Omer; Atug, Fatih; Alev, Burcin; Cevik, Ozge; Bulbul, Nurdan; Yarat, Aysen; Cetinel, Sule; Sener, Goksel; Kulaksizoglu, Haluk (WILEY, 2018)Aims: Urethral stricture (US) formation is caused by fibrosis after excessive collagen formation following an injury or trauma to the urethra. In this study, we aimed to evaluate the effects of platelet-rich plasma (PRP) ... -
Resveratrol treatment may preserve the erectile function after radiotherapy by restoring antioxidant defence mechanisms, SIRT1 and NOS protein expressions
Sener, Tarik Emre; Tavukcu, Hasan Huseyin; Atasoy, Beste Melek; Cevik, Ozge; Kaya, Ozlem Tugce; Cetinel, Sule; Degerli, Ayse Dagli; Tinay, Ilker; Simsek, Ferruh; Akbal, Cem; Buttice, Salvatore; Sener, Goksel (NATURE PUBLISHING GROUP, 2018)Radiotherapy (RT) for prostate cancer (PC) can cause erectile dysfunction (ED) by damaging neurovascular structures with oxidative stress. In this study, we evaluated the effects of resveratrol, an antioxidant, on post-RT ... -
Riboflavin Treatment Reduces Apoptosis and Oxidative DNA Damage in a Rat Spinal Cord Injury Model
Sakarcan, Sinem; Ersahin, Mehmet; Eminoglu, Mehmet Emin; Cevik, Ozge; Ak, Esin; Ercan, Feriha; Sener, Goksel (AVES PRESS LTD, 2017)Objective: Spinal cord injury (SCI) leads to an inflammatory response and results in oxidative stress, which has deleterious effects on several organ systems. Riboflavin is an easily absorbed micronutrient that plays an ...